Posts tagged as:

mTOR

Thoughts on the Aubrey de Grey/Colin Blakemore Debate

May 15, 2012

By Robert Kane Pappas
On April 25th, Aubrey de Grey participated in a debate with Professor Colin Blakemore – neuroscientist and ex-head of the Medical Research Council, UK’s largest funding body for bio medical research – at Oxford University’s Sheldonian Theatre. The debate’s title was: “Resolved this house wants to defeat aging entirely” and was to [...]

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The Aging Tree

March 2, 2012

By Robert Kane Pappas
“The Low Hanging Fruit” 
When discussing aging interventions – slowing down the aging process – note that there are causal relationships between aging, age related diseases, health span and lifespan. 
To make a further distinction, the pace of the application of various breakthroughs can be broken down into a second hierarchy: think of it [...]

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Aging and Disease — a comment by Robert Kane Pappas

March 15, 2011

Last week, Vince Giuliano wrote a probing blog about aging and disease, which can be found on this site and on agingsciences.com.  I contributed a video clip. One of his underlying points is that a disease which is cured by stimulating one of these regulator genes — for instance SIRT1 or mTOR –- will likely [...]

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Aging and Diseases — Video Blog

March 12, 2011

Everyone knows that old age can lead to many diseases and problems.  And sooner or later one of those diseases or problems will kill everybody.    But, what exactly is the relationship of aging to diseases?  The question leads to surprisingly interesting answers.
First, please have a look at this video for opinions of some prominent scientists:

Here, [...]

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Practical Steps to Reduce the Risk of Alzheimer’s Disease

November 5, 2010

In a previous post (click here), Robert Kane Pappas highlighted the promising research results relating to Alzheimer’s disease (AD) based on one study by a team led by Gizem Donmez in Dr. Lenny Guarente’s Lab at MIT and another involving rapamycin, an anti-rejection drug that targets the mTOR gene.  Translating promising results in the lab [...]

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Thoughts on New Aging Conference by RKP

October 4, 2010

Robert Kane Pappas Comments on the New Aging Conference and his Conversation with Dr. Brian Kennedy 
I have been on the road this past week – filming Dr. Brian Kennedy (the new CEO of the Buck Institute) at the Cold Spring Harbor Lab’s Fall Conclave of Molecular Biologists; and speaking on aging research at the University of [...]

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Alzheimer’s Research — Connecting the Dots

September 9, 2010

RKP Comments on Recent Articles on Promising Research Results Relating to Alzheimer’s Disease
The first article is a press release from MIT on the research conducted by Dr. Guarente’s Lab.  Click here to read the article.  The second, an article posted on PLoS One, describes the effect of  rapamycin on AD progression.  Click here to read [...]

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PROMISING RESULTS IN RAPAMYCIN STUDY ON OLDER MICE

March 15, 2010

Followers of To Age Or Not To Age may be interested in this study on the effect of rapamycin (a compound found in bacteria from Easter Island) on elderly mice, which was reported in an article by Brandon Keim, Cancer Drug Delays Aging in Mice, originally published in Wired on July 8, 2009.
According to the article,
“the study provides [...]

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